Warfarin is an anti-clotting agent prescribed for patients with irregular heartbeat, heart attack, heart valve replacement surgery, stroke, major surgeries or clotting disorders. The optimal Warfarin dose depends on the patient's diet, age, genetic variants, and the use of other medications. Patients with genetic variants require twice the number of days for stabilization of Warfarin dose as compared to those without any variations. Because of the risk of severe bleeding Warfarin is probably under-prescribed. At AyuGen Biosciences we perform a test to predict the sensitivity of an individual to Warfarin, before the drug is prescribed. We test for genetic markers in 2 genes, CYP2C9 and VKORC1, which are associated with Warfarin’s metabolism and site of action respectively.
USFDA has recommended using the genotype information before starting the Warfarin therapy.